Correlation of Methylation Assay and Bisulfite Sequencing Data to Determine the Epigenetic Regulation of miR17-1 in an Alzheimer's Disease Model
Proposal Type
Poster
Location
Jerry Falwell Library, Lower Esbenshade Atrium
Start Date
11-4-2015 2:00 PM
End Date
11-4-2015 5:00 PM
Correlation of Methylation Assay and Bisulfite Sequencing Data to Determine the Epigenetic Regulation of miR17-1 in an Alzheimer's Disease Model
Jerry Falwell Library, Lower Esbenshade Atrium
Current research done by our team indicates that there are epigenetic modifications on genes coding for miRNAs in an Alzheimer’s disease (AD) model. miRNAs are involved in the post-transcriptional regulation of genes and may play a role in the pathology of AD. miR17-1 showed epigenetic significance from MspI/HpaII methylation assays and miRNA expression levels. Bisulfite sequencing was used to analyze miR17-1 for site-specific CpG methylation to further the understanding of AD pathology.
