Category
Theoretical Proposal
Description
It is estimated that approximately 70% of individuals worldwide consume caffeine daily. A plethora of genes contribute to caffeine metabolism, out of which CYP1A2 is responsible for 90%. Two prominent CYP1A2 alleles are *1A and *1F which metabolize caffeine at fast and slow rates respectively. Retrospective research has demonstrated *1F possessing individuals are at an increased risk for nonfatal myocardial infarction. However, the acute electrocardiographic and physiological cardiac responses to caffeine across a range of doses remain poorly characterized. The goal of the proposed study is to evaluate the physiological changes of the heart, using an ECG, in individuals who possess the *1F allele. We hypothesize that *1F individuals, especially those who are subject to higher caffeine doses, will experience acute physiological heart changes not seen in *1A*1A individuals. The data provided by this study will allow the refinement of caffeine consumption recommendations based on caffeine sensitivity and the development of novel therapeutics to treat the adverse cardiac responses studied.
Genotype-Dependent Cardiac Responses to Caffeine: Acute Electrocardiographic Effects Across CYP1A2 Gene Variants
Theoretical Proposal
It is estimated that approximately 70% of individuals worldwide consume caffeine daily. A plethora of genes contribute to caffeine metabolism, out of which CYP1A2 is responsible for 90%. Two prominent CYP1A2 alleles are *1A and *1F which metabolize caffeine at fast and slow rates respectively. Retrospective research has demonstrated *1F possessing individuals are at an increased risk for nonfatal myocardial infarction. However, the acute electrocardiographic and physiological cardiac responses to caffeine across a range of doses remain poorly characterized. The goal of the proposed study is to evaluate the physiological changes of the heart, using an ECG, in individuals who possess the *1F allele. We hypothesize that *1F individuals, especially those who are subject to higher caffeine doses, will experience acute physiological heart changes not seen in *1A*1A individuals. The data provided by this study will allow the refinement of caffeine consumption recommendations based on caffeine sensitivity and the development of novel therapeutics to treat the adverse cardiac responses studied.
