Category
Basic
Description
Type 2 diabetes mellitus (T2DM) is the most prevalent form of diabetes worldwide and represents a growing global health concern. T2DM is characterized by chronic fasting hyperglycemia and is increasingly associated with alterations in the gut microbiome. This study tests the hypothesis that heat stress, a gut dysbiosis-associated stressor, will upregulate the fructose transporter GLUT5 in enterocytes. Increased GLUT5 expression may enhance intestinal fructose uptake, thereby contributing to worsened glycemic control in T2DM. While the mechanism linking inflammation and impaired glucose homeostasis remains elusive, emerging evidence supports strong associations among gut dysbiosis, systemic inflammation, and insulin resistance.
Stress and Fructose Uptake In Enterocytes
Basic
Type 2 diabetes mellitus (T2DM) is the most prevalent form of diabetes worldwide and represents a growing global health concern. T2DM is characterized by chronic fasting hyperglycemia and is increasingly associated with alterations in the gut microbiome. This study tests the hypothesis that heat stress, a gut dysbiosis-associated stressor, will upregulate the fructose transporter GLUT5 in enterocytes. Increased GLUT5 expression may enhance intestinal fructose uptake, thereby contributing to worsened glycemic control in T2DM. While the mechanism linking inflammation and impaired glucose homeostasis remains elusive, emerging evidence supports strong associations among gut dysbiosis, systemic inflammation, and insulin resistance.
