Identification of select low-molecular weight compounds, found in coffee, that promote glucose homeostasis in 3T3-L1 adipocytes

Identification of select low-molecular weight compounds, found in coffee, that promote glucose homeostasis in 3T3-L1 adipocytes

Poster - Basic

Type-2 diabetes (T2D) is a major health concern and continues to be on the rise, currently affecting around 462 million people globally. One promising area of research is the pursuit of novel, natural, cost-effective methods of T2D treatment and prevention. Recent research shows a negative correlation between coffee consumption and T2D, indicating studies dedicated to the examination of coffee and its contents could reveal bioactive compounds that might prove useful in this pursuit. Polyphenols have been well-reported to attenuate several complications associated with T2D including inflammation, hypertension, and oxidative stress. Interestingly, previous work has indicated that several polyphenols that are naturally found in coffee, including enterodiol, secoisolariciresinol, and cafestol have the ability to promote glucose uptake in skeletal muscle cells. However, whether these effects extend to adipocytes is yet to be determined. In this study, we demonstrate that these coffee-derived polyphenols indeed promote glucose uptake in 3T3-L1 adipocytes. We also provide updated insight into the molecular mechanisms by which this is accomplished.