Publication Date

5-2026

School

School of Nursing

Major

Nursing (B.S.N.)

Abstract

Postural Orthostatic Tachycardia Syndrome, otherwise known as (POTS) is a neurological condition that affects the autonomic nervous system. POTS often presents in adolescent women. This review looks at research surrounding possible treatment modalities including pharmacological and non-pharmacological interventions. The goal of this review is to increase healthcare provider knowledge surrounding POTS and increase the speed and efficiency at which POTS is diagnosed and treated in adolescents. This will be done by surveying the current research for best treatment methods, common comorbidities, and reasoning for delayed diagnosis. Common symptoms seen in POTS include syncope and pre-syncope, dizziness, fatigue, and decreased cognitive function. Significant findings found within the research include increased COMPASS-31 score - which is used to measure the level of autonomic dysfunction - is linked to decreased cognitive functioning. Secondly, medication treatment of POTS is extensive and complex. Medication treatment of this disease requires multiple mediations, and medication choice should be based on patient-based symptomology. Research on treatments of POTS is very limited so this review will also evaluate the gaps within research.  The gaps found were that there was limited research on pediatric POTS leading to inconclusive evidence for any treatment modality. The limitations of the research found included small sample size, single center studies, and retrospective design. All these limitations lead to a risk of the data found being ungeneralizable to the normal pediatric POTS population.

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