Publication Date
5-2026
School
School of Health Sciences
Major
Biology: Pre-Med
Keywords
24-Methyl Cholesterol, Clear Cell Renal Cell Carcinoma, Glucose Metabolism
Disciplines
Biochemical Phenomena, Metabolism, and Nutrition | Heterocyclic Compounds
Recommended Citation
Chung, Josiah S., "Molecular Mechanisms of 24-Methyl Cholesterol a Therapeutic Agent in Clear Cell Renal Cell Carcinoma via Modulation of Cellular Glucose Metabolism" (2026). Senior Honors Theses. 1611.
https://digitalcommons.liberty.edu/honors/1611
Abstract
Cancer is a leading cause of death worldwide, with over 400,000 new cases of kidney cancer diagnosed globally and 80,000 new cases in the US in 2024. Our lab has demonstrated that 24-methylcholesterol (24-MC) inhibits glucose uptake in a dose-dependent manner in Caki-1 clear cell renal cell carcinoma (ccRCC) cells and suppresses NAMPT and AMPK activity in a ccRCC model. ccRCC exhibits unique glucose transporter profiles that support the elevated energy demand associated with rapid cell proliferation. These findings suggest that 24-MC may represent a novel metabolic therapeutic strategy for renal cancer. Further investigation is warranted to evaluate its mechanistic actions and clinical potential.
Included in
Biochemical Phenomena, Metabolism, and Nutrition Commons, Heterocyclic Compounds Commons
