Publication Date

5-2026

School

School of Health Sciences

Major

Biology: Biomedical Sciences

Keywords

Parkinson's, Treatments, aDBS

Disciplines

Medicine and Health Sciences

Abstract

Parkinson’s disease (PD) is a neurodegenerative disease closely associated with the accumulation of α-synuclein in neurons, and inhibition in the release of dopamine, a key neurotransmitter of the nervous system. Disruption in dopamine signaling can cause cognitive and motor dysfunctions, with tremor, bradykinesia, and rigidity being the most observable effects. There is no permanent treatment for PD, constituting the need for further research to improve current pharmaceutical approaches and possibly develop a cure. Main areas of research include improving medication via delivery methods, genetic mutation using CRISPR, and adaptive deep-brain stimulation. Recent developments and applications in these areas will be reviewed, in addition to future possibilities.

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