Publication Date
5-5-2024
School
School of Health Sciences
Major
Biology: Biomedical Sciences
Keywords
bronchopulmonary dysplasia, neonatal diseases, microbiology, lung pathology, pathophysiology
Disciplines
Congenital, Hereditary, and Neonatal Diseases and Abnormalities | Diseases | Medicine and Health Sciences | Pulmonology
Recommended Citation
Jacob, Anjali, "Bronchopulmonary Dysplasia: Pathophysiology and the Effects of the Microbiome" (2024). Senior Honors Theses. 1426.
https://digitalcommons.liberty.edu/honors/1426
Abstract
Bronchopulmonary dysplasia (BPD) is a chronic neonatal lung disease that occurs in over 50% of premature infants. BPD is characterized by damage to the alveoli and bronchioles and improper vasculature formation. It is primarily caused by overexposure to oxygen through mechanical ventilation, but there are other risk factors that make infants more susceptible to BPD. Microbial composition impacts risk for developing BPD, and research is ongoing about the effects of the microbiome on BPD pathogenesis; this information is also valuable for preventative treatment. This paper reviews the normal function of the lungs, pathogenesis of BPD and how it affects normal lung function, and the current and ongoing research concerning the effects of the microbiome on BPD.
Included in
Congenital, Hereditary, and Neonatal Diseases and Abnormalities Commons, Pulmonology Commons
