Publication Date

4-2024

School

School of Health Sciences

Major

Biology: Biomedical Sciences

Keywords

Genome Editing, CRISPR, OMEGA, Fanzor, Medical applications, Ethics

Disciplines

Medicine and Health Sciences

Abstract

A little more than a decade ago, CRISPR-Cas system was identified as a potential gene editing tool. This RNA-guided DNA cleavage system, which naturally provides immunity to the prokaryotic host cell, has been engineered since for its application in agriculture, genomic screening, and hereditary genetic disorder treatment and cures. Recently, a eukaryotic CRISPR-Cas-like system, Fanzor, was reported, under a new class of the RNA-guided system (termed OMEGA). The discovery has increased the potentials of genetic modification more than ever, while simultaneously increasing the need for ethical considerations and guidelines. The history, structure, and functions of the two RNA-guided systems, as well as their current and prospective applications, and the ethical and social issues surrounding genomic modification through specific case studies are discussed in this thesis.

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