Publication Date
4-2024
School
School of Health Sciences
Major
Biology: Pre-Med
Disciplines
Medical Molecular Biology
Recommended Citation
Bosch, Katherine Renee, "The Role of PFKFB3 in AMPK-Activated GLUT4 Translocation" (2024). Senior Honors Theses. 1379.
https://digitalcommons.liberty.edu/honors/1379
Abstract
Type 2 diabetes is a chronic, potentially deadly disease that impacts millions of Americans’ lives. Type 2 diabetes is characterized by increased blood glucose levels caused by insulin resistance. The normal insulin signaling pathway leads to glucose uptake by GLUT4 through activation of the IRS-1-PI3K-Akt pathway, as well as the insulin-independent pathway that utilizes AMPK. Additionally, PFKFB3 may play a role in insulin signaling and glucose uptake. PFKFB3 is an enzyme that plays an important role in activating PFK-1, which is a rate-limiting enzyme in glycolysis. PFKFB3 is frequently studied for its role in cancer due to its role in cell proliferation and differentiation. However, little is known about its involvement in insulin signaling.
