School of Health Sciences
Biology: Biomedical Sciences
T Cell Therapy, Immunology, Cancer
Medical Immunology | Oncology
McCloy, Griffin, "T Cell Therapy: Underlying Mechanisms and Current Advancements" (2022). Senior Honors Theses. 1158.
As the second leading cause of death in 2016, cancer is one of the most serious diseases facing the world today. T cell therapy is a current area of research attempting to address the disease with two primary division: CAR-T and TCR-T cell therapy. The immune system naturally produces T lymphocytes to aid in the recognition and removal of cells infected with viruses or transformed into cancer. Under normal circumstances, T lymphocytes identify and destroy cancerous cells; however, some cancerous cell types can evade this system. With the use of genetic editing technology, T lymphocytes can gain the ability to recognize these evasive cancers. The editing process is known as T cell therapy.