Publication Date

Spring 5-3-2020

School

School of Health Sciences

Major

Biology: Pre-Med

Keywords

acute lymphoblastic leukemia, ALL, pediatric, cognitive deficits, chemobrain, executive function, computerized cognitive training, oxidative stress, leukoencephalopathy, genetic polymorphisms, pharmacological interventions, nonpharmacological interventions

Disciplines

Cancer Biology | Cognitive Neuroscience | Developmental Biology | Developmental Neuroscience | Molecular and Cellular Neuroscience

Abstract

The improved survival rate for pediatric cancer patients is one of the greatest triumphs of recent medicine, but the late effects faced by these survivors have been uncovered through this new population of survivors. Many survivors of pediatric acute lymphoblastic leukemia (ALL) experience cognitive deficits in areas such as attention, memory, processing speed, and academic achievement following cancer treatment. Recent research has pointed to chemotherapeutic agents, host risk factors, and genetic predispositions as perpetrators of these deficits, although other factors are also under investigation. Consequently, the search for appropriate interventions for the amelioration of these deficits has dominated the literature in recent years. Due to the individualized and multi-faceted nature of the late effects, universally effective remediation methods are still nonexistent. However, pharmacological, non-pharmacological, and computerized cognitive intervention methods have all shown considerable promise for counteracting these cognitive deficits.

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