School of Nursing


Doctor of Nursing Practice (DNP)


Folashade Odedina


statin therapy, cardiovascular accidents (CVAs), Type 2 diabetes, efficacy, adherence, cost-effectiveness, patient-centered care, statin risk reduction, clinical outcomes




This study was an integrated review that comprehensively analyzed the efficacy of statin therapy in mitigating the risk of cardiovascular accidents (CVA) among individuals with type 2 diabetes mellitus (DM). The research seeks to explore statin management in preventing CVAs, a significant concern for this patient population. The study conducts a thorough synthesis of twenty-one peer-reviewed articles, critically evaluating the efficacy, safety, adherence factors, and cost-effectiveness of statin therapy for diabetic patients. The study adhered to the Whitmore and Knafl Framework and used the constant comparison approach to systematically categorize and pattern findings, culminating in an integrated understanding of statin therapy's impact on CVA risk. The research results demonstrate a consistent and noteworthy reduction in CVA incidence among type 2 DM patients receiving statin therapy, showcasing a relative risk reduction of 30% in CVA incidence. The study stresses the efficacy of statin therapy in significantly reducing low-density lipoprotein cholesterol levels, a pivotal risk factor for cardiovascular diseases in DM patients. Safety evaluation revealed minimal adverse effects, emphasizing modern-intensity statins over high-intensity therapy and warning against use in patients with high 10-year CVD risk and rheumatoid arthritis patients who may suffer autoimmune complications. Furthermore, the project addresses critical aspects of clinical scholarship and analytical methodologies, employing rigorous analysis to synthesize existing literature. The findings advocate for statin therapy's integration into diabetes management guidelines, bridging the realms of scientific underpinnings, interprofessional collaboration, and advanced nursing practice. The findings have substantial implications for clinical practice and the overall well-being of the diabetic patient population, promoting evidence-based interventions and improved patient outcomes.

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