School of Nursing


Doctor of Nursing Practice (DNP)


Dorothy Murphy


Obesity, Depression, Intervention, Adult, Comorbid




Obesity and depression share a bidirectional relationship when they exist as comorbidities in addition to individually posing complex public health challenges. Evidence from recent years suggests that there is a benefit to treating these illnesses with an integrated approach when they co-occur, but no current clinical guideline exists for this approach. The purpose of this integrative review is to synthesize existing literature and report current interventions targeting the management of comorbid obesity and depression in adults. The Whittemore and Knafl methodology for integrative review is the framework used to conduct this synthesis. A systematic search was conducted of nine computerized literature databases through the database platform EBSCOhost. The initial search yielded 587 results. After filtering by a priori inclusion and exclusion criteria, there were 14 articles included in the final review. Existing collaborative interventions have demonstrated usefulness in improving both obesity- and depression-related primary outcomes. Some secondary outcomes of quality-of-life and metabolic measures were also improved. Oral nutritional supplementation may also be an important component of these interventions, but do not stand alone in effectiveness in improving primary outcomes. There are gaps in the knowledge about the most effective forms of collaborative intervention for this patient population, but studies included in this sample provide an ample base of support for guiding future research initiatives.

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