Ets in the Kidney—Unraveling the Molecular Mechanism Underlying Renal Damage in Salt-Sensitive Hypertension

Publication Date

11-2017

Document Type

Article

Disciplines

Medicine and Health Sciences

Abstract

Originally identified as a homolog of a viral oncogene (v-ets), the ETS family of transcription factors consists of over 25 proteins involved in regulating several biologic processes at the transcriptional level. The ETS DNA binding domain consists of a winged helix conformation and binds the DNA sequences 5′-GGA(A/T)-3′ with varying affinity depending on ETS phosphorylation status, epigenetic modifications, and various protein-protein interactions.

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