School of Health Sciences
Biology: Biomedical Sciences
Alzheimer's Disease, Parkinson's Disease, Huntington's Disease, Neurodegenerative Disease, Tau protein, amyloid, Polyglutamine, Huntingtin, Dementia
Nervous System Diseases
Mack, John, "Protein Aggregates and Polyglutamine Tracts In Neurodegenerative Disease" (2018). Senior Honors Theses. 815.
The incidence of neurodegenerative diseases such as Alzheimer's Disease, Parkinson's Disease, Huntington's Disease and other Polyglutamine Diseases is projected to dramatically increase throughout the developed world, and yet the pathology of these diseases remains poorly understood. One pathway that these neurodegenerative diseases share is the accumulation of pathologic proteins which are not only harmful in their soluble form but may go on to form toxic aggregates. In many cases, a consensus has yet to be reached concerning the mechanism for protein aggregation. Therefore, the exploration of the roles of these proteins and their possible mechanisms, along with potential techniques for treatment, are more important than ever.