School of Health Sciences
Townsend, Brigitte Elyse, "Inhibition of Anterograde Microtubule Transport Leads to Mitrochondrial Transit Deficiency and Alzheimer's-Like Pathology" (2006). Senior Honors Theses. 771.
Alzheimer's disease is a neurodegenerative disorder providing a wide variety of molecular topics for investigation. Although apoptosis pathways have been the particular focus in recent years, identifying the mechanisms that stimulate intracellular transport disruption could provide the key to understanding the disease and potentially being able to prescribe remedies that will prevent the biochemical malfunctions. Disruption of mitochondrial transport is a highlight of the transport research focus and the focus of this project. By integrating immunocytochemistry, fluorescent microchondria and other vesicles in control and Staurosporine-treated cells were examined. Although mitochondria could not be distinguished as well as originally hoped, this project paved the way for future studies using combined fluorescence and MEDIC tracking to follow the pathways of particular vesicles through a cell, and provides groundwork for assessing the cause of the peri-nuclear clustering effect evident in tissues following apoptotic or Alzheimer's-mimicking tissues.