School of Health Sciences
Biology: Biomedical Sciences
MRSA, PBP2a, Antibiotics, Herbal Extracts
Genetics and Genomics | Immunology and Infectious Disease | Medicine and Health Sciences | Microbiology | Pharmacology, Toxicology and Environmental Health
Makullah, Mgayya R., "Current Antibiotics and Future Herbal Extract Methods to Treat Methicillin-Resistant Staphylococcus aureus (MRSA): Focusing on Inhibition of Penicillin-Binding Protein 2a (PBP2a)" (2016). Senior Honors Theses. 642.
Methicillin-Resistant Staphylococcus aureus (MRSA) has developed resistance towards a number of antibiotics. This resistance creates a challenge when trying to treat MRSA with a number of antibiotics. This is mainly caused by the penicillin-binding proteins 2a (PBP2a). PBP2a have significantly less affinity for beta-lactam antibiotics compared to the other penicillin-binding proteins (PBPs) expressed by non-resistant strains. New treatments involving a combination of antibiotics and herbal extracts are being developed and used to inactivate PBP2a, allowing the previous ineffective antibiotics to be more effective.