Publication Date

Spring 4-27-2025

School

School of Health Sciences

Major

Biology: Biomedical Sciences

Keywords

Parkinson's Disease, Mitochondrial Dysfunction, Neurodegenerative Disease, Alpha-synuclein

Disciplines

Diseases | Medical Neurobiology | Nervous System Diseases | Neurology

Abstract

Parkinson’s disease is a neurodegenerative disorder, caused by the damage to and death of dopamine-releasing neurons in the brain. The substantia nigra is a major region housing dopaminergic neurons and plays a critical role in motor and cognitive function. When these neurons are compromised, dopamine levels decline, leading to the development of motor and cognitive dysfunction. Current treatments include dopamine precursors, which help to replace dopamine and relieve motor symptoms. However, while there is symptomatic treatment for Parkinson’s disease, there are no preventative therapies or cures. A potential link between mitochondrial dysfunction and Parkinson’s disease has prompted further research. Investigating how mitochondrial function contributes to neuronal degradation may reveal novel therapeutic targets and treatment strategies.

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