Publication Date

Spring 4-23-2025

School

School of Health Sciences

Major

Biology: Biomedical Sciences

Keywords

Hyperglycemia, Type 1 Diabetes, Cognition, Depression, pre-clinical study, dementia

Disciplines

Biochemistry | Biology | Chemicals and Drugs

Abstract

An empirical study tested the effects of Type 1 Diabetes (T1D) on cognitive function in a hyperglycemic mouse model. Strong correlations between mental illnesses, such as major depressive disorder, neuropathologies like Alzheimer’s disease, and diabetes suggest comorbid pathology. Considering the prevalence of both T1D and cognitive decline within the general population, the findings were relevant and aimed to identify early signs of cognitive decline in diabetic patients. Behavioral tests and immunohistochemical staining were utilized to determine the cognitive function of the mice, revealing decline or deterioration caused by hyperglycemia. Data gathered from the hyperglycemic or control mice were analyzed based on sex to distinguish the unique symptom loads exhibited by male and female mice.

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