Publication Date

Spring 4-2023

School

School of Health Sciences

Major

Exercise Science: Therapeutic

Disciplines

Nephrology | Other Analytical, Diagnostic and Therapeutic Techniques and Equipment | Other Chemicals and Drugs | Surgical Procedures, Operative | Therapeutics

Abstract

Donor kidneys are damaged upon circulatory death before being preserved with machine perfusion until transplantation. During machine perfusion, blood is pumped back into the vasculature of the kidney, causing damage called ischemic reperfusion injury. The two forms of machine perfusion are hypothermic machine perfusion and normothermic machine perfusion. Different methods of treatment can be used during either hypothermic machine perfusion or normothermic machine perfusion to prevent ischemic reperfusion injury. Each of the treatment methods that were reviewed showed potential for preventing ischemic reperfusion injury, with hypothermic treatments having higher average levels of feasibility than normothermic treatments. The effect of the analyzed treatments on graft function after transplantation is likely positive, so a conclusion can be drawn that undergoing any one of the treatment methods will lead to positive results after transplantation.

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