In Vitro Gametogenesis: A Research Timeline and Implications for the Future of Assisted Reproductive Technology
School of Health Sciences
Biology: Biomedical Sciences
IVG, Stem Cells, ART, In Vitro-Derived Eggs, In Vitro-Derived Sperm
Bioethics and Medical Ethics | Medical Cell Biology | Medical Molecular Biology
Buckley, Nicole, "In Vitro Gametogenesis: A Research Timeline and Implications for the Future of Assisted Reproductive Technology" (2023). Senior Honors Theses. 1292.
The novel reproductive technology, In Vitro Gametogenesis (IVG), includes the process of obtaining mature viable germ cells from pluripotent stem cells. To do so, embryonic stem cells and induced pluripotent stem cells are specified to primordial germ cells and differentiated to form gametes that undergo further maturation, which subsequently may undergo in vitro fertilization to form an embryo. With this capability, IVG holds the power to provide a novel treatment option for human infertility. As of now, research has been conducted on mice successfully, and with limited success in humans. Future research will likely focus on discovering the species-specific differences between mice and humans through studies with nonhuman primates. Research on large mammals such as the rhinoceros will also contribute to animal conservation efforts. While human IVG has not been fully developed yet, several concerns have arisen regarding the ethical and legal implications of this technology. While none of these concerns are tangible due to the current state of research findings and current International Society for Stem Cell Research guidelines, they may inform legislation in the future.
Bioethics and Medical Ethics Commons, Medical Cell Biology Commons, Medical Molecular Biology Commons