Publication Date
Spring 4-14-2023
School
School of Health Sciences
Major
Biochemistry and Molecular Biology
Keywords
Pharmaceuticals, Chromatography, Analytical Methods, High-Performance Liquid Chromatography, Stationary Phase, Chemical Gradients, Stationary Phase Gradients, Pharmacological Research, Separation Science, Drug Analysis, Drug Development
Disciplines
Complex Mixtures | Medicinal and Pharmaceutical Chemistry | Pharmaceutical Preparations | Pharmaceutics and Drug Design
Recommended Citation
Klose, Hannah, "The Application of Continuous Stationary Phase Gradients to High-Performance Liquid Chromatography and Its Potential to Improve Pharmacological Research" (2023). Senior Honors Theses. 1263.
https://digitalcommons.liberty.edu/honors/1263
Abstract
The separation of mixtures into different components is integral to experimentation and analysis in a multitude of fields. Chromatography is one of the most popular, well-developed, and well-studied methods used to examine the makeup of a mixture. Thus, the improvement of chromatographic procedures directly benefits research across many scientific disciplines. The application of a continuous stationary phase gradient to High-Performance Liquid Chromatography (HPLC) methods has been proposed to improve the separation of complex mixtures that are difficult to achieve with existing separation techniques. By incorporating a gradient stationary phase, analysts will create a more selective mode of separation to improve the efficiency and cost-effectiveness of their research. Particularly, this new protocol will enhance the function of the pharmaceutical industry, which relies heavily on chromatographic methods.
Included in
Complex Mixtures Commons, Medicinal and Pharmaceutical Chemistry Commons, Pharmaceutical Preparations Commons, Pharmaceutics and Drug Design Commons
