Title

Defining the Role of a Putative SREBP Cleavage Activating Protein in pH Response Regulation in Cryptococcus neoformans

Publication Date

4-2022

School

School of Health Sciences

Major

Biochemistry and Molecular Biology

Keywords

Cryptococcus neoformans, virulence, pH, adaptation, SREBP-CAP, SREBP, Scp1, ergosterol, membrane homeostasis

Disciplines

Genetics | Pathogenic Microbiology

Abstract

Cryptococcus neoformans is a fungal pathogen that infects the lungs and travels to the central nervous system where it causes meningoencephalitis. Without rapid medical intervention, this is fatal for individuals with compromised immune systems. During infection, the pathogen moves from an acidic exterior environment to a slightly alkaline environment in the host. This induces alkaline-specific gene induction to maintain cellular processes for cell survival. Investigators at Duke University identified several genes that play a role in this process, including CNAG_01580, or SCP1, which codes for a putative SREBP cleavage activating protein. This gene was deleted in wild-type C. neoformans to assess alterations in virulence-related phenotypes. If this gene significantly impacts virulence, it will provide a new target for antifungal therapy.

This document is currently not available here.

Share

COinS