School of Health Sciences
Biology: Biomedical Sciences
Curcumin, Turmeric, Cardiovascular, Cell Signaling, Cell Signalling, NF-kB, JNK1, atherosclerosis, aneurysm, cardiomyopathy, supplementation
Alternative and Complementary Medicine | Biological Phenomena, Cell Phenomena, and Immunity | Chemicals and Drugs | Circulatory and Respiratory Physiology | Diseases | Medical Biochemistry | Pharmacy and Pharmaceutical Sciences
Richfield, Mary, "JNK and NF-κB Cell Signaling Pathways in Cardiovascular Disease Present Potential Targets for Curcumin Therapy" (2022). Senior Honors Theses. 1193.
Curcumin (diferuloylmethane) is a compound derived from the rhizomes of Curcumin longa that has been long used for medicinal purposes. Curcumin alleviates the pathology of cardiovascular diseases, including atherosclerosis, aneurysm, and cardiomyopathy. The mechanism of curcumin therapy is under active research. The NF-κB and JNK pathways are two that curcumin interacts with to block inflammatory processes, apoptosis, and fibrotic tissue remodeling to prevent the pathologies of cardiovascular disease. While curcumin has demonstrated powerful mediation of cardiovascular disease, its bioavailability in body tissues is limited due to the instability and hydrophobicity of its structure. Further work is underway to stabilize curcumin in vivo and enhance its biodistribution using plant compounds like piperine, nanoemulsions, and nanoparticles.
Alternative and Complementary Medicine Commons, Biological Phenomena, Cell Phenomena, and Immunity Commons, Chemicals and Drugs Commons, Circulatory and Respiratory Physiology Commons, Diseases Commons, Medical Biochemistry Commons, Pharmacy and Pharmaceutical Sciences Commons