School of Health Sciences
Biology: Molecular Biology
cancer development, Intracellular calcium
Biochemistry | Cellular and Molecular Physiology | Genetics | Medical Cell Biology | Medicinal Chemistry and Pharmaceutics | Molecular Biology | Neoplasms
Anderson, Emma, "Investigation of Oncogenic RAS and Endoplasmic Reticulum-Mitochondria Calcium Flux and their Relationship in the Context of Tumorigenesis" (2022). Senior Honors Theses. 1188.
Intracellular calcium as a signaling molecule is a pervasive feature of cellular pathways, especially those that manage internal homeostasis and transitions through the cell cycle, so much so that regulated, responsive calcium flux between the endoplasmic reticulum (ER) and the mitochondria has been suggested to play a major role in cancer development. Another factor commonly implicated in tumorigenesis is RAS, an oncogene that controls signaling for many pathways that are also regulated by calcium. While both calcium and oncogenic RAS signaling are implicated in cancer development, possible links between them have yet to be determined. The identification of these links will provide a further understanding of the mechanisms of cancer development and potential therapeutic targets for cancer treatment.
Biochemistry Commons, Cellular and Molecular Physiology Commons, Genetics Commons, Medical Cell Biology Commons, Medicinal Chemistry and Pharmaceutics Commons, Molecular Biology Commons, Neoplasms Commons