School of Health Sciences
Biochemistry and Molecular Biology
Mixed Connective Tissue Disease, MCTD, autoimmune, blocking antibodies, blocking antigens, in silico, autodock, chimerax, avogadro, vina, autodock vina, antibody, antigen, proposed treatment
Allergy and Immunology | Computational Chemistry | Immune System Diseases | Pharmaceutics and Drug Design
Russell, Thomas, "A Proposed Treatment of Mixed Connective Tissue Disease by Competitive Inhibition of Autoantibodies" (2022). Senior Honors Theses. 1172.
Mixed Connective Tissue Disease is an autoimmune disease characterized by Raynaud’s phenomenon and arthritis among other symptoms. It is primarily caused by antibodies that target the U1-RNP 70K peptide. The treatment proposed in this paper uses competitive inhibition to prevent the binding of the anti-U1-RNP 70K antibodies with the U1-RNP 70K peptide. A method for testing the designed treatment in silico is proposed using AutoDock Vina docking software.