Publication Date

Spring 5-15-2021


School of Health Sciences


Biology: Biomedical Sciences


Technology, Mitral Disease, Valve replacement, Heart Disease, Biotechnology, Medical Devices


Cardiology | Medical Biotechnology


The mitral valve is a two-cusp valve that is located between the left atrium and left ventricle of the heart. As blood flows from the lungs and enters the atrium, it must pass through this valve in one direction to enter the ventricle and be pumped out to the systemic circuit.

Mitral valve disease occurs when normal mitral valve function is impaired. Many different repair and replacement options exist. These options are contingent upon age and risk factors for patients. This paper focuses on the four main transcatheter mitral valve replacement devices that have limited human trials. It concludes that while the technology serves a niche purpose in the status quo, much greater progress will need to be made to make it the prevailing technological procedure to treat heart valve disease in the United States and worldwide.