Publication Date

Spring 2021


School of Health Sciences


Biology: Biomedical Sciences


mRNA, vaccines


Biology | Medicine and Health Sciences


mRNA vaccines for the prevention of infection disease have gained significant traction in the last three decades, specifically with the recent emergency approval of two COVID-19 vaccines (Oliver, Sara E et al., 2020; Rauch et al., 2018a). mRNA vaccines occupy a unique space in immunology because of their utilization of cellular mechanisms to produce viral proteins, and their simplicity and ease of manufacture (Cullis & Hope, 2017). These vaccines have shown strong humoral and cell-mediated adaptive immune responses (Rauch et al., 2018b) . In addition, side effects of the vaccines have been limited and subject response is manipulatable by varying the lipid nanoparticle (LNP) vector of the vaccine (Sedic et al., 2018; Zhang, N. et al., 2020). This thesis will provide an in-depth review of the types, mechanisms, and safety of mRNA vaccines, as well as a history of mRNA technology and the current advancements of the field.