School of Health Sciences
Biology: Biomedical Sciences
Biology | Medicine and Health Sciences
Underhill, Isaac, "mRNA Vaccinations for the Prevention of Viral Infections" (2021). Senior Honors Theses. 1083.
mRNA vaccines for the prevention of infection disease have gained significant traction in the last three decades, specifically with the recent emergency approval of two COVID-19 vaccines (Oliver, Sara E et al., 2020; Rauch et al., 2018a). mRNA vaccines occupy a unique space in immunology because of their utilization of cellular mechanisms to produce viral proteins, and their simplicity and ease of manufacture (Cullis & Hope, 2017). These vaccines have shown strong humoral and cell-mediated adaptive immune responses (Rauch et al., 2018b) . In addition, side effects of the vaccines have been limited and subject response is manipulatable by varying the lipid nanoparticle (LNP) vector of the vaccine (Sedic et al., 2018; Zhang, N. et al., 2020). This thesis will provide an in-depth review of the types, mechanisms, and safety of mRNA vaccines, as well as a history of mRNA technology and the current advancements of the field.