Publication Date

Fall 11-23-2020


School of Health Sciences


Biochemistry and Molecular Biology


Chemotherapy, aptamer, Lung Cancer, Norcantharidin


Biology | Chemical and Pharmacologic Phenomena | Medical Cell Biology | Medicine and Health Sciences | Molecular Biology


Lung Cancer is the leading cause of cancer related death in both men and women in the United States (Bray et al., 2018). Cancer treatments are often non-specific and kill many dividing cells within a patient causing unwanted side effects. Norcantharidin (NCTD) is a synthetic FDA approved treatment for cancers including non-small cell lung cancers (NSCLC). NCTD suppresses cell proliferation by inhibiting cells from exiting the G2 phase of the cell cycle. Aptamers are short single-stranded DNA or RNA molecules with ligand directed self-annealing capabilities allowing selective binding to specific targets. This paper will discuss the hypothesized effects of using a single-stranded DNA aptamer bound to NCTD to reduce proliferation of A549 cells, an adenocarcinoma cell line often used to study NSCLC (Foster et al., 1998 & Giard et al., 1973).