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Christian missionaries experience numerous stressors across multiple domains. To understand their unique experiences, a targeted assessment is required. There is no known psychometrically tested measure that captures the nuances of stress for this population. To that end, as part of a larger study, the quantitative CHOPS Stress Inventory, a new tool for measuring missionary stress was developed and showed good initial psychometric qualities when compared to an established stress measure. Furthermore, the Analysis of covariance (ANCOVA) of survey findings on 267 cross-cultural evangelical missionaries noted that both age and sex demonstrated significant effects on perceived stress scores. Implications for missionary member care services and recommendations for future research are discussed.