Document Type


Publication Date



Previous work by our group has demonstrated a correlation between AD pathology and changes in epigenetic markers, including cytosine methylation of gene promoter regions. Several genes determined to have AD-related changes in methylation code for miRNA, which is known to regulate gene expression at a post-transcriptional level. Research suggests that miRNA play a key role in AD development by alteration of gene products and transcription factors, particularly in that of amyloid-ß (Aß) production and apoptosis of postmitotic neurons. This analysis shows a significant up-regulation of demonstrated epigenetically modified miR-17 in the hippocampi of transgenic AD mice when compared to that of non-AD mice. MiR-17 belongs to the polycistronic cluster miR-17-92 and is believed to be involved in normal neuronal cell proliferation and ultimately the regulation of Beclin-1, which has been shown to modulate amyloid beta accumulation in mice.


This poster presentation won first place at the Big South Undergraduate Research Symposium (BigSURS), held April 10-11, 2015 at Campbell University.