Senior Honors Theses

Author(s)

Daniel MorinFollow

Publication Date

Spring 5-1-2018

School

School of Health Sciences

Major

Biology: Biomedical Sciences; Exercise Science: Pre-Professional

Keywords

Spinal, Cord, Spine, Vertebrae, Vertebral, Spinal Cord, Spinal Column, Trauma, Injury, Primary injury, Secondary injury, ROS, Astrogliosis, Glutamate, Exitotoxicity, Free Radical, Glial, Research, Nervous, CNS, Central Nervous, Treatment, Research, Therapy, Therapies

Disciplines

Biology | Critical Care | Emergency Medicine | Medical Anatomy | Medical Cell Biology | Medical Immunology | Medical Neurobiology | Medical Pathology | Medical Physiology | Molecular and Cellular Neuroscience | Musculoskeletal, Neural, and Ocular Physiology | Nervous System | Nervous System Diseases | Neurology | Neurosciences | Orthopedics | Other Medical Sciences | Other Neuroscience and Neurobiology | Other Rehabilitation and Therapy | Pathological Conditions, Signs and Symptoms | Pharmacy and Pharmaceutical Sciences | Sports Medicine | Trauma

Abstract

The structures of the spinal cord and vertebral column are designed to provide flexibility, while still providing ample protection for the spinal cord deep within. While it does offer remarkable protection against most routine trauma, the spinal cord is still vulnerable to high-force etiologies of trauma and may become damaged as a result. These events are referred to as primary injury. Following the initial injury, the body’s own physiological responses cause a cascade of deleterious effects, known as secondary injury. Secondary injury is a major therapeutic target in mitigating the effects of spinal cord injury (SCI), and much research is currently being done to develop more effective treatment options.

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