Senior Honors Theses

Author(s)

Travis FehrFollow

Publication Date

2017

School

School of Health Sciences

Major

Biochemistry and Molecular Biology

Keywords

Dehaloperoxidase, Hemoglobin, Peroxidase, Peroxygenase, Heme, Oxidation

Abstract

Dehaloperoxidase (DHP) is a multifunctional enzyme found in Amphitrite ornata, a sediment-dwelling marine worm. This enzyme possess the structure of a traditional hemoglobin enzyme and serves as the primary oxygen carrier in A. ornata; however, it also possesses peroxidase and peroxygenase capabilities. These secondary oxidative functions provide a remarkable ability for A. ornata to resist the effects of toxic metabolites secreted by other organisms that cohabit its benthic ecosystem. This study will analyze the novel catalytic switching between peroxygenase and peroxidase oxidation mechanisms employed by DHP in response to pH changes.

Share

COinS