Senior Honors Theses

Publication Date

Fall 11-18-2016

School

School of Health Sciences

Major

Biology: Biomedical Sciences

Keywords

MRSA, PBP2a, Antibiotics, Herbal Extracts

Disciplines

Genetics and Genomics | Immunology and Infectious Disease | Medicine and Health Sciences | Microbiology | Pharmacology, Toxicology and Environmental Health

Abstract

Methicillin-Resistant Staphylococcus aureus (MRSA) has developed resistance towards a number of antibiotics. This resistance creates a challenge when trying to treat MRSA with a number of antibiotics. This is mainly caused by the penicillin-binding proteins 2a (PBP2a). PBP2a have significantly less affinity for beta-lactam antibiotics compared to the other penicillin-binding proteins (PBPs) expressed by non-resistant strains. New treatments involving a combination of antibiotics and herbal extracts are being developed and used to inactivate PBP2a, allowing the previous ineffective antibiotics to be more effective.