Publication Date
Fall 11-18-2016
School
School of Health Sciences
Major
Biology: Biomedical Sciences
Keywords
MRSA, PBP2a, Antibiotics, Herbal Extracts
Disciplines
Genetics and Genomics | Immunology and Infectious Disease | Medicine and Health Sciences | Microbiology | Pharmacology, Toxicology and Environmental Health
Recommended Citation
Makullah, Mgayya R., "Current Antibiotics and Future Herbal Extract Methods to Treat Methicillin-Resistant Staphylococcus aureus (MRSA): Focusing on Inhibition of Penicillin-Binding Protein 2a (PBP2a)" (2016). Senior Honors Theses. 642.
https://digitalcommons.liberty.edu/honors/642
Abstract
Methicillin-Resistant Staphylococcus aureus (MRSA) has developed resistance towards a number of antibiotics. This resistance creates a challenge when trying to treat MRSA with a number of antibiotics. This is mainly caused by the penicillin-binding proteins 2a (PBP2a). PBP2a have significantly less affinity for beta-lactam antibiotics compared to the other penicillin-binding proteins (PBPs) expressed by non-resistant strains. New treatments involving a combination of antibiotics and herbal extracts are being developed and used to inactivate PBP2a, allowing the previous ineffective antibiotics to be more effective.
Included in
Genetics and Genomics Commons, Immunology and Infectious Disease Commons, Medicine and Health Sciences Commons, Microbiology Commons, Pharmacology, Toxicology and Environmental Health Commons
