College of Arts and Sciences
Primary Subject Area
Biology, Genetics; Biology, Molecular
Alzheimer's Disease, Apolipoprotein E, Epigenetics, Diet
Genetics | Molecular Genetics
McMullen, Kelly C., "Contributions of Apolipoprotein E and Environmental Factors in Alzheimer’s Disease" (2013). Senior Honors Theses. 363.
Alzheimer’s disease (AD) is a debilitating neurodegenerative disorder, which currently affects nearly 5.5 million people in the United States alone. Clinical features often exhibited in AD include memory loss, unusual behavior, personality changes, and impaired cognitive function. The primary molecular hallmarks of AD include deposits of senile plaques and neurofibrillary tangles in brain tissue. A myriad of risk factors are associated with the disease, but this review will focus on Apolipoprotein E polymorphisms and certain environmental factors. Understanding the role of Apolipoprotein E in AD pathology may aid in the development of certain drug therapies and possible cures for AD. Moreover, epigenetic mechanisms such as deoxyribonucleic acid (DNA) methylation are equally important in understanding AD pathology. Environmental factors may have the potential to induce the epigenetic mechanisms associated with AD. As a result of these new findings, the focus of some AD research has recently shifted to a preventive approach in understanding AD pathology. The relationship between Apolipoprotein E polymorphisms and environmental factors in AD pathology will address the importance of preventive measures that can be taken in regard to AD.