College of Arts and Sciences
Primary Subject Area
Biology, Molecular; Biology, Cell; Biology, Physiology
Laminin deficiency, protein, muscular dystrophy, Congenital Nephrotic Syndrome, Junctional Epidermolysis Bullosa
Cell Biology | Congenital, Hereditary, and Neonatal Diseases and Abnormalities | Molecular Biology | Skin and Connective Tissue Diseases
Reynolds, Joshua Mark, "Analysis of the Effects and Current Treatments of Laminin Deficiency" (2012). Senior Honors Theses. 284.
Laminin (LM) is a network of proteins that functions as a connective framework of most cells in the body. It is composed of multiple different subunits and therefore has many different variations. It is a trimeric protein, meaning that it is composed primarily of ⍺, β, and γ chains. The differentiation of these subunits is what gives the different variants their functions. In addition, although LM is the primary molecule in scope, the network of other connective proteins involved in LM-associated diseases will also be covered in lesser detail because molecules like dystrophin, dystroglycan, collagen, and integrin are vital to the understanding of how LM can influence the body. Current treatments are typically symptomatic, and if cures are to be found, the focus needs to be on the root cause.