Senior Honors Theses

Publication Date

Spring 2012

School

College of Arts and Sciences

Major

Biology: Pre-Med

Primary Subject Area

Biology, Anatomy; Biology, General

Keywords

Ankylosing Spondylitis, AS

Disciplines

Medicine and Health Sciences

Abstract

Ankylosing Spondylitis (AS) is an autoimmune disease that occurs in an adult-onset or juvenile-onset form. The symptoms, severity, and prevalence of this disease vary according to sex, age, and race. AS has been strongly associated with the gene that codes for protein HLA-B27, a protein that misfolds in AS and causes stress on the Endoplasmic Reticulum (ER). The ER then sets off a chain of events leading to the observed AS symptoms. Other mutant genes such as Interleukin 23R (IL23R) and ER Amino Peptidase 1 (ERAP1) have been associated with AS, though not as prominent as HLA-B27. AS is thought to have a genetic basis that accounts for many cases of familial inheritance, though cases have been observed in patients with no family history of AS or with a lack of associated genes. There is much research needed to determine the etiology and map the behavior of Ankylosing Spondylitis.

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