Publication Date
8-2024
School
School of Health Sciences
Major
Biology: Biomedical Sciences
Disciplines
Medicine and Health Sciences
Recommended Citation
Hall, Sierra, "Effects of Cafestol and Enterolactone on Glucose Uptake in 3T3-L1 Differentiated Adipocytes" (2024). Senior Honors Theses. 1443.
https://digitalcommons.liberty.edu/honors/1443
Abstract
A review of current literature has revealed that moderate habitual coffee consumption is inversely associated with the risk of T2D development. Cafestol (CF) and enterolactone (ENL), two bioactive compounds found naturally in coffee, have been shown to promote glucose disposal in skeletal muscle and basal glucose uptake in L6 myotubes, respectively. However, the anti-diabetic effects of these compounds on adipose tissue and the mechanisms they utilize have not yet been characterized. Thus, in this study, the effects of CF and ENL on adipose tissue were determined by differentiating 3T3-L1 fibroblasts into adipocytes and treating them with either compound in a concentration-dependent manner. The results of this investigation suggest that both compounds stimulate glucose disposal in adipocytes via a GLUT4-dependent mechanism.
